Multi-resistant KPC germs detected in more than 50 patients
At the University Hospital Leipzig (UKL), multidrug-resistant KPC (Klebsiella pneumoniae) pathogens have been found in numerous patients in the past two years. According to the hospital's official announcement, 58 patients have been affected by an infection since the pathogens were first detected in 2010.
"The KPC germ, which has so far not been widespread in Northern Europe, has tended to be on the rise in recent years," reports the university hospital. In Leipzig, the pathogen was first detected in July 2010 in a patient who came from a Greek clinic. The patient was immediately isolated and all necessary protective measures were taken, reports the clinic. The subsequent microbiological examinations of fellow patients and the surrounding area would have revealed no evidence of transmission. However, despite the "barrier measures, there was a big delay three months later in autumn 2010 to an outbreak-like accumulation on several wards," the university hospital said. The medical team then recorded the largest KPC epidemic to date in Germany with 30 affected patients until the wave of infections was contained in February 2011.
58 patients infected with multidrug-resistant pathogens In January 2011, the University Medical Center Leipzig informed the responsible health office about the spread of the CCP infections, since there is a compulsory notification in the event of frequent occurrence of hospital infections. However, “from today's perspective, this notification could have been made earlier,” said Professor Wolfgang E. Fleig, Medical Director of the University Hospital Leipzig, self-critically. Even after the wave of infections has been contained, isolated infections with the CCP germs have repeatedly occurred at Leipzig University Hospital. Since February 2011, up to four cases of KPC evidence have been recorded per month in patients admitted or transferred to the university hospital. This year alone, eight other patients have been infected with the multi-resistant pathogens. In total, the KPC germs have so far been detected in 58 patients in Leipzig, whereby almost all those affected were treated for severe “underlying diseases such as liver failure requiring transplantation in the UKL”, the official announcement of the clinic.
Transmission chain of multidrug-resistant pathogens not yet finally interrupted The first outbreak of the CCP infections "could be contained by additional preventive measures, but the transmission chain could not be interrupted yet", reports Professor Fleig in the press release "Containing a rare multidrug-resistant germ at Leipzig University Hospital" . Successful prevention of further new infections can only be achieved if there is an intensive search for possible CCP carriers outside the university hospital. The UKL experts assume that many patients did not become infected with the germ in the clinic, but have already brought it in with them. "To the best of our knowledge, the occasionally occurring KPC evidence at the UKL is not connected to a currently active source in the UKL," emphasized Prof. Fleig and added: "It is very likely that the patients will repeatedly bring the germ into the UKL." However, employees continue to look for possible transmission channels.
Health risks from the CCP Regarding the health risks from the CCP, the doctors explained that "it is known that the course of the disease of inpatients treated by inpatients is negatively influenced by colonization or infection with multidrug-resistant bacteria." This also applies to infections by the multidrug-resistant CCP germs. Difficulties often arise, particularly in treatment, due to the antibiotic resistance of the pathogen. This was also confirmed by Klaus-Dieter Zastrow from the German Society for Hospital Hygiene, who explained that it often takes a long time to determine an effective antibiotic for treatment. According to the doctors, three antibiotics are still available for the treatment of the KPC germs that were detected at Leipzig University Hospital.
Multi-resistant CCP germs more widespread in southern Europe While the germs in northern Europe have so far only been detected occasionally, they have been relatively widespread in some southern European countries for a long time. According to the UKL announcement in Greece, more than 25 percent of Klebsiella pneumoniae bacteria have “resistance demonstrated by the UKL or a similar resistance” and “in Italy the rate is five to ten percent.” However, the spread of infections that can be observed in Leipzig remains According to Klaus-Dieter Zastrow, "more than exceptional for German standards." (fp)
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