Heroin addiction could be stopped by new drug
According to the latest study results, morphine or heroin addiction could be stopped in the future. The newly developed preparation "plus-naloxon" is intended to reduce the release of dopamine in the brain's reward center. However, the drug has not yet been clinically tested, as the researchers report in the US journal "Journal of Neuroscience".
A blockage in the brain prevents the desire for opiates, explains Mark Hutchinson from the Australian School of Medical Sciences in Adelaide. The effects of opiates such as heroin or morphine take place via so-called immune receptors (TLR4) in the brain, which increase dependency.
Against heroin addiction, dopamine releases in the brain are to be slowed down
"Taken together, the data indicate that the mode of action of opiates on classic opiate receptors, together with their newly discovered mode of action on TLR4, influence the mesolimbic dopamine system, which increases an increase in extracellular dopamine levels caused by opiates," they write Scientist. The preparation "plus-naloxon" is said to reduce the flare-ups of the messenger substance dopamine in the brain reward center and to reach a level "that corresponds to that of eating, sex or hugs", explains Hutchinson. For some time it has been suspected that TLR4 receptors are one "but now we have the evidence," says Linda Watkins of the Center for Neuroscience at the University of Colorado.
The scientists see the use of “plus-naloxon” mainly in the relief of severe pain, while preventing dependency. It can also be used with drug addicts. (ag)
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