Tired fat cells cause disturbed insulin processing
According to a US study, lack of sleep causes a fat cell disorder that reduces its sensitivity to the energy hormone insulin. Overweight, diabetes and other illnesses can result. The tired fat cells should also increase the feeling of hunger.
Tired fat cells may make you feel more hungry.A research team led by Matthew Brady from the University of Chicago conducted a study to investigate why lack of sleep causes an increased risk of obesity, diabetes and other health problems.
The scientists selected six women and one man for their study who were young, healthy and of normal weight. The subjects slept 8.5 hours each on four consecutive nights. A blood test showed insulin processing in the body. A small amount of abdominal fat tissue was also removed from the study participants. In the following four nights, the subjects slept only 4.5 hours. The food remained the same during the investigation period.
As the evaluation of the blood and tissue samples showed, the subjects reacted 16 percent less well to insulin after the four-day lack of sleep. The fat cells were even 30 percent less sensitive to the energy hormone. According to researchers, the laboratory results are very similar to those of overweight and diabetic people. According to this, there is a biochemical dependence on lack of sleep and fat and sugar regulation in the body.
"Many view fat cells as a problem, but in fact they are vital," reports Matthew Brady. "When they are stored, they pull fat molecules out of the body's circulation, where they could damage other types of tissue." Failure of the fat cells to respond adequately to insulin due to lack of sleep can cause disorders that lead to diseases such as obesity and diabetes. Because fat cells also produce the hormone leptin, which creates a feeling of satiety and curbs appetite, the insulin processing problem could also mess up this household and cause even more hunger, the researchers said.
Lack of sleep affects metabolism A connection between lack of sleep and an increased risk of obesity, diabetes and other diseases was also investigated by Orfeu Buxton from Brigham and Women's Hospital in Boston and his team. The scientists found that too little sleep encourages underactive pancreas. Accordingly, people who work shifts or who frequently have to take intercontinental flights are more likely to develop Type II diabetes. Lack of sleep and a shift in the day-night rhythm leads to a disturbance in the internal clock, as the scientists report. The pancreas would therefore produce less insulin, so the sugar would concentrate in the blood. An increased blood sugar level can in turn cause diabetes. The scientists also found that the subjects' metabolism was slower at rest, which increased the risk of being overweight.
Lack of sleep affects brain function In another study, Marie-Pierre St-Onge from Columbia University Medical Center and her team demonstrated that people who sleep too little have a greater appetite for unhealthy food. Due to the lack of sleep, certain reward centers are activated in the brain, which require calorie bombs such as chocolate or hamburgers for the reward effect. In addition, deprivation of sleep causes impairment of higher-level brain functions, which make decisions based on reason. However, areas related to instinct continue to function without restriction, so that decisions with the mind, for example, to counteract the desire for unhealthy food, can only be made to a limited extent. When there is enough sleep, the brain areas function normally, so that there is no overdimensional craving for chocolate, ice cream or fast food. (ag)
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