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Curcumin can reduce metastases

Curcumin can reduce metastases

Curcumin inhibits daughter tumors

In arthritis and other ailments, the goldenseal is known as a remedy in natural medicine. It contains an active ingredient, polyphenol curcumin, which inhibits inflammation and can also prevent the formation of metastases, as a team of scientists has now shown.

A team of researchers from the LMU Munich investigated the active ingredient curcumin because it inhibits the formation of daughter tumors. This natural polyphenol is very well tolerated and would potentially be suitable for use both for primary tumor prevention and for secondary tumor prevention in an already advanced tumor stage.

In tumors that are associated with chronic latent inflammation, such as prostate or breast cancer, the cytokines CXCL1 and CXCL2 are increasingly formed. The scientists were able to demonstrate that curcumin specifically inhibits the synthesis of these proteins. Tests on mice showed that the formation of metastases could be reduced. The development of daughter tumors in the lungs of the animals in breast and prostate cancer was statistically significantly reduced.

However, this does not mean that this substance should replace the current therapy strategies, emphasizes the research team. “Rather, it is conceivable to use curcumin before a tumor has been diagnosed - or to prevent the formation and spread of metastases. Good tolerability is very important to us because we would then like to recommend the use of curcumin to a healthy population group with an increased risk of tumors. ”(Original publication: Kilian, PH, et al. Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2.Carcinogenesis online; doi: 10.1093 / carcin / bgs312, 2012)

Image: Franz Eugen Köhler, Köhler’s medicinal plants

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