Brain development impaired by BPA

Brain development impaired by BPA

Bisphenol A affects brain development

Once again, a study by US scientists found the negative effect of the plastic base material bisphenol A (BPA) on brain development. As the news agency "dpa" reports, the researchers led by psychologist Frances Champagne from Columbia University in New York were able to demonstrate in mice that BPA has a lasting effect on the brain development of the animals. The scientists published their results in the journal “Proceedings of the National Academy of Sciences” (PNAS).

Bisphenol A is contained in numerous plastics as a so-called plasticizer, but tooth fillings and receipts also have considerable BPA concentrations in some cases. There has long been a discussion about the possible health impairments due to the increased intake of BPA. The study by the US scientists has now shown that the unborn life is also massively influenced by the plasticizer. If pregnant mice ingested BPA, their offspring showed changes in brain development that were also reflected in the behavior of the animals. Even small doses of the plasticizer had a clear effect.

Even low BPA doses with a lasting effect
As part of their study, the US researchers administered between two and 200 micrograms of BPA per kilogram of body weight to the pregnant mice. A dose of 50 micrograms is considered a safe daily limit in Europe. But even at lower doses, the offspring of the contaminated animals already showed significant changes in behavior, the scientists report. For example, the male offspring of the mice contaminated with BPA were significantly more researched and daring than those who had not been exposed to animals. The female offspring, however, would have shown more anxious behavior than usual through the contact of the mothers with the plasticizer.

BPA causes changes in the estrogen receptors
The behavioral changes in the young had already occurred at supposedly safe doses, the scientists report. They attribute this, at least in part, to the effects of the plasticizer on the estrogen receptors in various areas of the brain. The BPA influences the receptors in the male cortex and in the female hypothalamus, Champagne and colleagues explained. In your opinion, BPA acts on the enzyme DNMT (DNA methyl transferase), which is used for gene regulation. The experts at the Federal Institute for Risk Assessment (BfR) are also concerned about the fact that even such low doses can have such a far-reaching effect on the brain, and Detlef Wölfle from BfR told the news agency “dpa” that they were “amazed at the effects of low ones Dosages. ”However, it remains unclear to what extent the current results can be transferred to humans. (fp)

Also read about BPA:
Hormone-like plasticizers in food
Dangerous plasticizers in food
Plasticizers cause diabetes and obesity
BUND: Increased plasticizer load in day care centers
Bisphenol-A leads to infertility in women
Environmentalists: BPA ban completely inadequate
Bisphenol A makes girls hyperactive and aggressive
Hormone-active chemicals threaten health

Photo credit: Mo Freiknecht /

Author and source information

Video: Brain Matters documentary. Early Childhood Development (September 2020).